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Noesis: lit. “understanding”, “intellect”, from the Ancient Greek νόησις.

Around 40 percent of adults aged 65 and over will report some kind of memory loss. New insights into the workings of the brain help with early detection of cognitive impairment. The learning and memory “hub” of the brain is known as the hippocampus, and includes the surrounding region, the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC). The LEC feeds memories into the memory hub and serves as a more specific time marker for memories.

Several recent studies in humans have pinpointed the LEC/MEC as the starting point for the onset for memory loss and Alzheimer’s Disease (AD). Early symptoms include losing track of the passage of time and dates, becoming disoriented, difficulty paying bills on time, and a weakening of the sense of smell. This may be a result of aging, medical conditions like hypothyroidism and inflammation, or early onset of AD. As there are no pharmaceuticals that help or cure the condition, a holistic approach to evaluation and treatment is recommended, including:

  • Entorhinal testing
  • Specific diet and modified exercises
  • Targeted phytonutrients
  • Neuro anti-inflammatories
  • Brain exercises and memory training

Stopping and reversing neurological decline is the clinical objective.

Consider our treatment protocol for memory loss and cognitive decline with Noesis at ExecutiveMD.


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Dr. John Mamana has been my Internist for over 20 years and his personalized care is what has kept me coming back. Day or night, Dr. Mamana is always available to help. His unique model of proactive medicine and unparalleled access for busy executives like me is invaluable. I am a customer for life.

Michael Shehadi,
Oxford Equity Partners

Contact Executive MD

1355 Beverly Road, Suite 220
McLean, Virginia 22101